Absolutely, it is possible.

I’m not sure about the depression, but it sounds plausible, depending on the experience. That’s out of my expertise, though.

For a concrete example, phantom limb pain can be a form of affective emotional pain, with a huge asterisk in that, it’s more complicated that than only resulting from #2. Too complex to get into in this forum. Here’s reading if you’re interested:

https://pmc.ncbi.nlm.nih.gov/articles/PMC6051014/#:~:text=.n...