The first is 3DSecure (or VbV). They are the most secure ways to accept credit cards, though they aren't as easy for users to use. However, they do go a long way to protecting the merchant. If your handling b2b transactions that are high risk, you might consider enforcing this. Again, it's not a solution to wield lightly, but it is a solution.
Also, you can require out-of-band authentication. Generally, this is in the way of making a telephone call, and requiring the user to input a 4-digit pin. This, combined with everything else, will help hinder potential fraud. More importantly, it helps to protect against friendly fraud.
Of the two, telephone authentication is easiest to implement, but do not discount 3DS for higher priced purchases.