That said, I think anything with kernel-level anti-cheat either does not run or runs poorly.
There is mention on the arch wiki about enabling multi-threaded compiles, but also I have read you perhaps dont even need to precompile them now and possibly get better performance as the JIT compiles via a different vulkan framework (VK_EXT_graphics_pipeline_library).
I disabled pre-caching (which effects the compile too afaict) and never noticed any stuttering, possibly past some level of compute it's inconsequential. I also noticed that sometimes the launcher would say "pre-compiling" but actually be downloading the cache which was a lot slower on my internet.
Certainly on my (very) old intel system with a GTX1060, Sekiro would try to recompile shaders every launch, pegging my system at 99% and running for an hour. I just started skipping it and never really felt it was an issue, Sekiro still ran fine.
I have a problem with Docker sockets while installing onto Bazzite, and didn’t care enough to look further into it.