The RickRoll'D Youtube video has over 63 million views, an incredible feat for an artist whose career all but died in the late 80s.
A 4chan meme making its way into Apple goes to show how influential that site can be.
Speaking of influential, check out the extensive Wikipedia page on the meme. The RickRoll has showed up in the Macy's Thanksgiving parade (with Rick Astley in person), a video from Nancy Pelosi, and a tweet from the White House Twitter feed. It is fully part of the pop culture.