This is an interesting one. I was of the impression that HFCS is worse for you than sugar cane, but in the past when I've repeated that statement here, I've had people disagree with it.
But, I just found this meta-analysis – https://pmc.ncbi.nlm.nih.gov/articles/PMC9551185/ – which suggests an association between HFCS consumption and increased CRP (C-reactive protein, a marker of inflammation)
A study (standard IN MICE disclaimer) suggesting that HFCS may contribute to NAFLD (non-alcoholic fatty liver disease) and NASH (non-alcoholic steatohepatitis) – https://www.nih.gov/news-events/nih-research-matters/how-hig... – and NASH sometimes (not always) progresses to liver cirrhosis, plus it also significantly increases the risk of liver cancer. The proposed mechanism is that fructose causes greater injury to the intestinal lining than other sugars, and the injured intestinal lining allows more bacterial toxins into the liver, which causes liver injury.