The Hypothesis explain phase [1][2] does this!

  fails_on_empty_third_arg(
      a = "",  # or any other generated value
      b = "",  # or any other generated value
      c = "",  
      d = "",  # or any other generated value
  )

[1] https://hypothesis.readthedocs.io/en/latest/reference/api.ht...

[2] https://github.com/HypothesisWorks/hypothesis/pull/3555