Ryan's budget and then follow on inclusion on this ticket might permanently kill the ability of the Republican party to elect someone to the presidency, if seniors (who vote primarily Republican) cross to the Democratic side of the ticket for their votes to protect their medicare. (Once someone has voted for candidates in both parties, they are considerably more likely to cross over and do so again in future elections).
Unemployment will most certainly be different between them.
His particular seat is not as valuable as being the brain trust and hit man in the Romney Ryan administration.
I can't find a good article to back that up with, though, so ymmv.
My own anecdotal evidence is that people believe what their news sources say more than they actually crunch numbers, so because of the polarization of news along political party lines people are going to believe whatever they see or read.