Why is it harder to firewall them with IPv6? I seems this would be the easier of the two to firewall.
Automated banning is harder, you'd probably want a heuristic system and look up info on IPs.
IPv4 with NAT means you can "overban" too.
It's also not a common metric you can filter on in open firewalls since you must lookup and maintain a cache of IP to ASN, which has to be evicted and updated as blocks still move around.