If you can exchange static content, you need very little scripting to be able to pull down new interactive pieces of functionality onto a page. Especially given that HTML and CSS are capable of so much more today. You see a lot of frameworks moving in this direction, such as RSCs, where we now transmit components in a serializable format.
Trade offs would have to be made during development, and with a complex enough application, there would be moments where it may be tough to support everything on a single page. However. I don’t think supporting single page is necessarily the goal or even the spirit of the web. HTML imports would have avoided a lot of unnecessary compilers, build tools, and runtime JS from being created for example.