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Comment by teej | Hacker News Reader

glp-1 inhibitors turn out to be better for alcohol and smoking cessation than any other drug we have. Truly a miracle drug.

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But they aren't actually prescribed for these things (yet?), right?

Some people say it's an "off-label" use -- but that's up to the doctor and patient ultimately.

But I think that's okay -- because the main purpose is weight loss and reduction of caloric cravings. Alcohol is a caloric craving. So it should be fine.

That wasn't their main purpose as they were brought to market. Even the anti obesity is an off label use.

I don't think it would get me off alcohol though. I only drink to relax and be more social. Not because I enjoy it or the taste. But it means I drink rarely anyway.

I can tell you that being on it, food to me just tastes different.

So even if you didn't enjoy it, what typically happens to me anyway, is the off flavors get magnified.

Like the easiest one is Costco Chili. It tasted vastly different when I was off of it than on it. I taste more of the bitter notes. The complexity is more off putting to me.

I inject on say Sunday nights, and on Monday an IPA tastes terrible. But on Friday it tastes tolerable again. And this is a pretty consistent pattern I've noticed.

> Even the anti obesity is an off label use.

Off-label for Ozempic - the whole point of Wegovy is the “weight management” indication.

Reports from friends in the EU is that doctors are prescribing it for all sorts of things off label. Autoimmune, ADHD, OCD etc. I take it for ME/CFS and it works well for me, but I get grey market supply. I’ve been on a low dose of it for a few years now, I was already researching it when it became a craze, the mass adoption really helped dial in dose safety. A small percentage of people like myself are super sensitive to it and need much lower doses

Very similar here - have autoimmune issue that it basically fixes, but am also super sensitive - never went above 2.5 which feels strong, often do half or less that.

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