React's threejs/pixijs bindings are a great example of what vdom diffing can let you do.

Since they bring their own reconcile(a, b, diff) function to React, these libs can turn:

    const world = new World()
    const player = new Player()
    world.add(player)
    // somehow wire up the code to keep 
    // player.pos updated

Into:

    const [x, setX] = useState(0)

    return <World>
      <Player x={x} />
    </World>

In other words, you write declarative code, and it does the hard imperative work of adding/removing/disposing/updating things for you.

Just like how it helps you sync your data model to underlying stateful DOM nodes; the idea can be applied on top of any stateful system.