Covid-19 vaccines associated with a reduction in ovarian reserve in rats | Hacker News Reader

Covid-19 vaccines associated with a reduction in ovarian reserve in rats

pmc.ncbi.nlm.nih.gov

7 pointsb800h5 comments

The first study I would do after that would be to obtain all the components of the vaccine individually and test those one by one in the same conditions. The depending on the results you try combinations if you can't pinpoint it to a single component

This got flagged yesterday and I was pretty disappointed by that. The single post said it was FUD and linked a different study, which was on sperm, not eggs. And this study on rats is about a publication in the journal of virology, which I assume raises it above the level of FUD.

It may not be FUD, but it's a really minor result from an absolutely tiny (n=10) study in rats, out of a fairly minor Turkish university. At the very least I would add, "In a small number of rats in a single study" to the title, given the associated politics around vaccination these days, and the reality of how few people read beyond headlines.

There's also the omitted relevant comparison, which is live SARS-CoV-2 virus exposure with no vaccine.

I agree, just three minor comments:

* It's 3x10 rats, there are 3 groups (placebo, Pfizer, Sinovac) with 10 rats in each of them.

* From the research article (with minor edits for space):

   Parameter   Control G.   mRNA V. G.   Inactivated V. G.      p
  ----------  -----------  -----------  ------------------  -----
  Primordial  106.70±5.33   42.40±4.96         70.10±12.04  0.001

Whatever it means, it's an interesting difference. From https://en.wikipedia.org/wiki/Folliculogenesis#Phases_of_dev... it doesn't look like a short time problem.

But the T.A. in my physics lab class would have yelled at me for hours for using too many decimals.

* > "In a small number of rats in a single study" HN should add that automatically to the title of all submissions, and then dang/tomhow just remove the few cases where that dos not apply. I'm not sure if I must add a :) or a :( at the end of the sentence.

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