Wow... there are probably several ways we could lose the ability to fab semiconductors. We can look back through history at other periods where they "forgot" how to do various things. Brunelleschi's dome on the Florence Cathedral was the first major dome built in Europe in over a thousand years since the fall of the Western Roman Empire. They lost the knowledge of dome building. Should they have considered doing themselves in because they found themselves in the Dark Ages? We might forget how to do various very involved technical things like fab'ing chips, or we might lose the knowledge/and or ability to even build a fab, for example (just consider the supply-chain required to build a fab and consider how fragile some of those chains are). Yeah, it will mean that something really bad has likely happened, but that doesn't mean that it's the end and we should just go and kill ourselves. It will mean that there's been some kind of discontinuity, but it doesn't necessarily mean the end of humanity. People will still be able to grow crops, hunt, fish, etc (given a reasonable climate remains in enough places). Likely the population under these conditions will be much smaller but it doesn't mean that we can never recover as a species - sure, it might take 1000 years. That's ok, we go on just like ancestors before us who endured great hardship.