Let me put it this way: there are very few things I can think of that models should absolutely refuse, because there are very few pieces of information that are net harmful in all cases and at all times. I sort of run by blackstone's principle on this: it is better to grant 10 bad men access to information than to deny that access to 1 good one.

Easy example: Someone asks the robot for advice on stacking/shaping a bunch of tannerite to better focus a blast. The model says he's a terrorist. In fact, he's doing what any number of us have done and just having fun blowing some stuff up on his ranch.

Or I raised this one elsewhere but ochem is an easy example. I've had basically all the models claim that random amines are illegal, potentially psychoactive, verboten. I don't really feel like having my door getting kicked down by agents with guns, getting my dog shot, maybe getting shot myself because the robot tattled on me for something completely legal. For that matter if someone wants to synthesize some molly the robot shouldn't tattle to the feds about that either.

Basically it should just do what users tell it to do excepting the very minimal cases where something is basically always bad.