Reaper does it really well. It's just a minor nag ("hey, you used Reaper for xx:xx hours, would you consider paying?") and a 5-second wait on startup (not on every startup even, I think on every system reboot or something).
I like to think the developer specifically targetted this "redundant consecutive save" behavior knowing many users do this.
But it's probably more like "every X saves, only after Y time period since last nag", which only coincidentally triggers for me when I spam the save shortcut