If people can use one Azeron Cyborg with one hand (or two with two hands) as a way against carpal tunnel syndrome then 80% and 60% keyboards are likely just a hack to keep backwards compatibility whereas the better long term solution is likely a proper alternative (with e.g. chording).
That said, I'm happy with my 80% (not with the 60% due to it missing arrow keys which I sometimes use, for example with a shell). But vertical mouse with a lot of buttons are rare (Azeron Cyro is an exception), so for now I'm using a Logitech Vertical MX.
I'm rocking an MX Mechanical Mini and I'm overall quite satisfied with it, though it's frustrating that the single-touch switching between multiple paired receivers doesn't take the MX-series mouse with it; this seems like really obvious functionality to have left on the table. At the same time, it doesn't seem like any of the other premium/gaming peripheral makers have tried to integrate anything like this. It's just 1:1 peripheral to receiver dongle, and "get a KVM" if you have more than one device to control.