I remember coming across a livestream of someone whose line-making process was to zoom in and scrub over a tiny area repeatedly for several minutes to create the effect of a single ink brush stroke. The effect was pleasant and had a very intentionally designed quality to it, but I came back a few hours later and he had made hardly any progress. The goal he had in mind was really better suited for vector tools, but the machine wasn't stopping him in the way that paper would give out under intensive scrubbing. I'm quite sure, extrapolating that anecdote, that there's someone out there trying to intentionally design each pixel in a 4k image.
IMHO the single most important thing digital provides is new ways to see - I'll often direct students to use the threshold filter to discover new lighting shapes in references or indicate planning problems with their value structure.