One of the theories for why there were tires on top of the russian planes that were bombed is that it confuses automatic targeting systems by breaking up the profile of the airplane used in automatic target recognition systems.
Hell, even hobbyist level DIY drone stuff can be easily programmed to run an autonomous route with or without a radio link connection. This is a huge reason that GPS is just constantly jammed in this part of the world. If you can get a GPS signal on the battlefield, you can tell a drone to go destroy something.