The pro-Israel lobby has spent roughly 10-15M per year since 1990 except for the past 2-3 years when it has ramped up due to the war. This is hardly enough to offset the billions of dollars spent in U.S. politics.
For this to be true it would also require Israel to "buy" presidents who acted against Israel's interests (e.g. Obama and Biden who financially bolsered Iran). This seems unlikely.
The U.S. does not unconditionally fund and defend Israel. Most (75-90%) of U.S. Federal military aid to Israel is contingent on Israel buying from American companies. This effectively makes most funding a roundabout subsidy of American defense contractors. There are also human rights conditions and many others.
Israel and the U.S. actually have common interests in the Middle East. Contrary to some opinions, allowing Israel to cease to exist is not in the interest of the U.S. although I do support having Israel be less reliant on the U.S.
sources: https://www.opensecrets.org/industries/indus?cycle=All&ind=Q...
https://www.congress.gov/crs_external_products/RL/PDF/RL3322...