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I hope this ends up superseding Cython

Same, and I literally started Cython. :-)

What's your current take on Cython vs other options? E.g. DSLs and I guess PyO3?

I think that's one of the real strong use cases I see coming up.

If they can make calling Mojo from Python smooth it would be a great replacement for Cython. You also then get easy access to your GPU etc.