Could you explain how? Does it do something funky in the venv that uwsgi doesn't understand?

I am using uwsgi with uv. This is not to say the problems you are facing are not real, but it cannot be a 'fundamental incompatibility' if it is working in my case. Here is an example of a CLI invocation I am using for quick testing:

-- uv run uwsgi --socket 0.0.0.0:8080 --protocol=http -w foo.app:server --processes 2 --threads 2 --stats 0.0.0.0:9191 --