The simulation would be flawed. Von Braun wheels would have very significant Coriolis effects, so it'd be hard to distinguish whether any issues are due to reduced gravity or the Coriolis effects.
(I assume the astronauts in 2001 A Space Odyssey jogged in the direction that made themselves weigh more, to make their workout more intense.)
A big wheel may be too costly, but it can be replaced by either 2 identical bodies with a long link between them, or with a single body linked to a counterweight, in which case the cost would be only marginally greater than for the current spaceships.