Both clang/llvm and gcc can do alias checking at runtime if they can't at compile-time, which makes loops vectorizable without alias info, at the cost of a bit of constant overhead for checking aliasing. (there's the exception of gather loads though, where compile-time aliasing info is basically required)
And on the other hand there's good potential for benefit to normal code (esp. code with layers of abstractions) - if you have a `&i32`, or any other immutable reference, it's pretty useful for compiler to be able to deduplicate/CSE loads/computations from it from across the whole function regardless of what intermediate writes to potentially-other things there are.