Out of curiosity, are there examples of drug development that did poorly in animal models, but then did much better in human trials?
I'm guessing this is rarely tested since animal modeling is usually a gating factor for human testing?
I'm guessing this is rarely tested since animal modeling is usually a gating factor for human testing?
The catch here is that only two targets (PD(L)-1 and CTLA-4) turned out to work well in humans. All of the other immunotherapies that looked mediocre preclinically turned out to also be mediocre or entirely ineffective in humans.