At least the 401k, IRA, and HSA don't require knowing anything particularly arcane. Money goes in, don't touch until 59 1/2 (401k, IRA) or 65 (HSA).
529 plans can get a bit more complicated because you'll want one from your state (if your state has an income tax) and they may offer several, but then it's less about knowing tax code specifics than about what the differences are between their offerings.