Dominant subgroups in a species are dominant because their parents survived that last set of pressures (external death inducements) at a higher rate than other subgroups -- but won't necessarily see the same results with the current set.
Even 90 years ago, there was significant loss of life due to famine, so selection was towards people who could efficiently gain and store calories in a biological Keynesian strategy. Now we have the opposite problem -- abundance of life-sustaining food produced for cheap but good quality food is expensive (in the US -- many other parts of the world have their quality food cheaper but I digress). So there hasn't been enough pressure (external-induced death) for GLP-1.
As a species with a remarkable ability to modify its environment to suit our purposes, body response to disease is just another thing to modify.