In my own experience, such simplications begin to fall apart as soon as you find the slightest bit of complexity in what you're building upon them. As soon as something doesn't fit the mold, you adjust the mold - or worse, you adjust the something. The next thing you know, you're spending more time customizing your framework than you are being truly productive.

There is an inherent simplicity in HTML / CSS / JS that can be easily forgotten and difficult to replace. Each has its responsibility: Organization, Style, and Function - The combinations of these 3 simple entities are amazingly capable of representing the entire internet. That's a pretty difficult thing to simplify further.

Nonetheless, I like your approach and I wish you luck.