If you think of the refresh rate not as a constant frequency but as variable with user input, there are some cases where driving eink quickly in short bursts could make sense? It seems like this project offers a foundation for such a controller, where e-reader controllers are strictly optimizing for low refresh rates. E-ink is not going to be competitive for playing a video game or watching a video, but you can create a more responsive experience with less eye strain for typical tasks like marking up documents.