FWIW, I use noscript and had no issues. Granted there were some blank spots which I guess where ads.
I wanted to add that every time I use the internet without a blocker, it's so depressing to realize this is how a lot of people, mostly older, experience the Internet. Very sad as someone in the industry.
It doesn't always work though, I assume the major publishers are employing some counter-measures. Also generally javascript heavy websites.