Thanks. A researcher we work with has postulated that build-up of metabolic waste (amyloid and tau, among others) directly impairs the glymphatic system, leading to more build-up. A viscous cycle.

I don't think she's the first to postulate this, but I believe she is researching this relationship now.

Though work culture is an important one, we're somewhat more focused on the less self-imposed sleep challenges related to maternity and perimenopause/menopause.