The NPU is somewhat usable on RK3588(S(2)) boards, as long as the kernel you’re using is recent enough to have the latest NPU driver.
For a quick bring-up and implementation, take a look at this repo: https://github.com/Pelochus/ezrknpu
I have a Radxa Rock 5C (on Armbian) and it runs various models rather well. Trying to convert models is kind of a pain, though, so watch out.