Tried a Moonlander and hated it. My hands don't work with ortholinear. And I hated having to learn layers and layouts. Besides I have a real job and I use a proper IDE so I need my F keys, I like to use the Home/End/Page Up+Down keys, I learned to use the numpad efficiently, etc. I think most of what is told and sold in ergonomics is snake oil. I don't believe ortholinear is any good for it, and minimizing movement also seems really questionable to me. I'm working with comfortable 30-40 wpm and am still one of the most prolific and productive engineers at $work, typing speed is not important for many jobs.
I would like to continue be able to use regular keyboards efficiently and with little annoyance. Too often I'm traveling and stuck with the laptop keyboard. I have to accommodate Linux ($work), Windows (gaming), Mac (personal projects, open uni). That's already challenging enough to get these have similar shortcuts. I use a keychron K5 pro that supports all OSs. I can work efficiently in all situations, with all OSs, with just a single screen. Having a more specialized keyboard (or otherwise setup, like relying too heavily on multi-monitors), wouid overall surely be detrimental, during the times I could not use it.
What I've learned to avoid pain: Wrists should be straight. For me, a slim keyboard helps to achieve that, flat on the table. Hands should have some room apart, open chest. Small keyboards are bad for that, you'll want a 100% one, or a split. Do some lifting, have some muscles. Try a trackball, you might love it. Switch how you are sitting. The best sitting position is the next one. Get up to think, go for breaks. Don't overly specialize into some local/global optimum that is a moving target over your lifetime. Use defaults. Mostly boring setup with some minor personal tweaks can go a long way.