I really think it is the closest thing I have to a religion. It alters how I see the world, defines the way I think about how to approach problems, and consumes every waking moment of my life.
Of course, I've had many failed relationships either directly or indirectly for my career, and it has taken my health (I sustained a spinal injury at work) and best years of my life. I feel deeply uncomfortable when I am _not_ working and it is difficult for me to relax. Intellectually I recognise that it is deeply unhealthy but every time I write a grant everyone else in the world who applies is ranked and objectively compared to me -- and I can't shake this feeling that _they don't sleep_, so why should I? It's an absolute obsession and I go into this hyper-focussed mode when I _actually_ get things done and, when an experiment reveals something for the first time in the world, the feeling is amazing.
I've just won an academic prize and have a tenured post. I'm deeply, deeply insecure and have a very unhealthy relationship with work. Many academics I know – especially in medicine – are likely diagnosable with very real conditions...