League of Legends may well be that big breakthrough - major events draw more viewers than an average MLB game.
Still impressive numbers, but it's too easy to glance at them and think (and I'm not saying you were doing this) "esports getting more viewers than baseball!"
But in all seriousness, I think the MOBA genre may be just what it needs, whether that be LoL, DotA, HoN, or otherwise.