Here are my trouble letters in this font: http://i.imgur.com/ilkUV.png Note that there is no indication what letters these are other than by direction (which is really hard for many dyslexics).
Compare this to a regular font: http://i.imgur.com/mbi54.png Note that there are hints in the serifs that distinguish direction.
By reversing the regular serif font, you can see these hints: http://i.imgur.com/t1sxB.png=
Also, the kerning is pretty bad: http://i.imgur.com/A9PJk.png