Still waiting for dish washer safe keyboard and mouse…
The old model M's also had easy to replace keycaps so you could take them off and wash as often as you want. Only downside is the need to put them back on in the right place each time, which is tedious.
Not all electronic components are water safe, but most are. I have no idea how you figure out if your device is or not without taking it apart. If you do this "often" expect that screws will rust, or minerals will build up - each causing problems. However if you just wash once a year you can get a lot of junk out.
Plug the ending of the usb somehow (3d printed part?) and it would work?