https://www.youtube.com/watch?v=miJbW3i9qQc
https://www.youtube.com/watch?v=70vYj1KPyT4
... that said, of course there's some valid criticism of science funding underneath, and (the whole role, purpose, and status of) the academic sphere (with its traditions and privileges) which largely determines the outcome of how grant organizations end doing funding decisions.
still, I think it's correct to state that it's very hard to falsify the hypothesis, because it says that AD (Alzheimer's disease) goes through the following stages: unknown proximate cause leads to appearance of amyloid plaques which then irreversibility lead to Tau bundles (tangles) which inevitably lead to neurodegeneration which then show up as AD
the model states that by the time the plaques are there it's "too late"
of course there are drugs being tested to try to "solve" this from multiple angles, for example make the progression slow enough to "not matter", prevent the tau bundles, etc.
...
https://www.astralcodexten.com/p/in-defense-of-the-amyloid-h...
see also "In 2024, the amyloid-cascade-hypothesis still remains a working hypothesis, no less but certainly no more": https://www.frontiersin.org/journals/aging-neuroscience/arti...
in particular I recommend looking at this diagram that shows how the model has evolved over the decades: https://www.frontiersin.org/files/Articles/1459224/fnagi-16-...