My old company/offices had site internet provided by one of the top 50 UK Managed Service Providers. They swapped out the on-site router not many years ago as the fibre to site was being upgraded from 100mbit to gigabit and so a new Juniper firewall with GBE ports was required.
Turns out the newer, faster, shinier, though albeit lower model numbered'd Juniper SRX fundamentally didn't support passing SCTP data and suddenly we lost access to all our remote stuff that used it. Ended up on a call with the MSPs Head of Networks (who was not a stupid person), but their opening gambit was "Are you sure you mean SCTP? Oh. What is that then?"
There was also numerous weird kernel bugs with implementations on CentOS 5, 6 and 7 which all would manage to get themselves into weird states where only a reboot would clear - not really what you want from a multi-endpoint, 'copes and recovers well from network weirdness' tunnelling protocol.