SQLite against S3 can work with some clever tricks. The neatest version of that I've seen is still this WebAssembly one: https://phiresky.github.io/blog/2021/hosting-sqlite-database...

I also got sqlite-s3vfs working from Python a few months ago: https://simonwillison.net/2025/Feb/7/sqlite-s3vfs/

Both of these are very much read-only mechanisms though.