Why wouldn't F-Droid build their own playless Android fork where this is a non-issue?
And at the same time, the target audience interested in installing a custom Android fork would be much smaller than the potential target audience for F-Droid in its current form.
(Also, for the time being, a much more minimally invasive and less resource-intensive approach would be some sort of Shizuku-like approach, i.e. using the ADB network interface originally intended for wireless debugging.)