One could, but you'd need to model multiple scenarios. Surveys show a steady increase in driving for Thanksgiving in the US versus flying since 2020. The average distance according to the AAA is 549 miles, which is approaching the tipping point where flying is more efficient for single passenger trips. For longer trips the tipping point becomes 2+ passengers. Driving will also be worse for NO2 emissions and general ground level pollution.

And none of this touches on safety, which I think is worth considering.