As an American living in Denmark, I would personally prefer to bootstrap a business here rather than in the U.S., though it does depend on what kind of business. The main advantage to doing it here, imo, is that the healthcare story is solved, though maybe that'll be better in the U.S. after PPACA comes into effect in 2014. Another plus is better government support for small businesses: grants are available, and you can get some cheap early part-time employees by participating in subsidized internship programs intended to "upskill" people on unemployment. The main downside is high wages (though that matters less in tech, where wages are very high in the US, too), less access to venture capital if you're going the non-bootstrapping route, and some general problems from not being in the U.S. (less media visibility, problems with payment gateways, etc.).