There's been a lot of research done into "ego depletion" - basically, 100+ studies have found evidence that the ability to focus and make yourself get things done is an exhaustible resource, and then recent studies by Carol Dweck have indicated that your abilities to do so, in some sense, depend upon your mindset going in and whether you embrace the task to begin with. The logical place to answer this would be with an fMRI study, and the first such study was just published a week and a half ago. The abstract indicates they found something, but the article itself is paywalled:
http://scan.oxfordjournals.org/content/early/2012/09/20/scan...
Say that we find that ego depletion comes from a shortage of blood glucose in the brain. If that's the case, the cure could be as simple as stocking the microkitchens with M&Ms (man, maybe Craig Silverstein had the right idea 14 years ago). It's also known that certain stimulants like caffeine and amphetamines help you overcome your normal mental fatigue limits - the problem is that they often tend to create dependency and lose their effect if you chronically overuse them. The reason for looking into the physical mechanism is that we might then be able to find simple solutions that work and don't have long-term side-effects.
http://www.nytimes.com/2011/08/21/magazine/do-you-suffer-fro...