== Long version == Depends on: (i) the job, (ii) quality of CS degree, (iii) career ambition/plans, and (iv) companies/people/culture, (v) project, and (vi) your ability/motivation/persistence.
A lot of basic programming can be picked up over time if you are keen. For many people, structured education is helpful when learning more complex material -- concurrency, compiler construction, advanced data structures, optimisation.
Some companies insist on a CS/SE degree (esp. consulting). Some projects state that all engineers must have formal qualifications.
There are a lot of Dilbert bosses out there -- they do not know/care/will-ever-know about Github profiles. There are bosses that just want stuff done. If you ever have to work for them, a paper with shields on it helps.