Yeah man, those stupid hick rednecks in Appalachia should have just learned to code.
The current VP is a stupid redneck hick from Appalachia who … you can Google him.
Point is, one way of responding to regional decline (Appalachia was once the wealthiest part of America) is to move.
Though I wouldn't tell the rest what they should do. The guy I know had to live in MN for decades (where I met him) away from the rest of his friends and family - that is itself a large cost in lifestyle that I question if money makes up for.