NixOS makes this rather easy too. There exist modules for synapse, livekit, etc (MAS module is still a Pull Request, though) and the setup is quite doable: https://wiki.nixos.org/wiki/Matrix

However, you still need to know what you are doing (the manual helps) and connect the pieces (in theory there could be a nixpkgs module that does this for you but apparently nobody did bother). Once its done you can lean back.

I've been running my homeserver happily for > 5 years and it was fairly straightforward.