I haven't heard her say that there's anything wrong with being trans, that it's an illness, or that there should be any consequences. I have heard her decry the excesses of some trans activists and allies, particularly in her defense of women-only spaces. That seems to me to be a poor fit for "asshole".
To her, trans women are really cis men pretending to be women, to make it easier to rape them. There’s kind of no nice way of saying it.
It’s textbook transphobia / queer bashing. Fear of sexual assault at the hands of queer people is probably one of the most basic reasons to justify this particular brand of bigotry. “I don’t hate queers, I’m just concerned for the safety of -“ take your pick - women, children, sometimes even men. For JK it’s women.
Using a dogwhistle instead of more well-known hate speech does not mean a person is innocent of bigotry - quite the opposite.