For example, we're not remotely close to having a standardized "watch form-factor" appliance interface.
Physical reality is always a constraint. In this case, keyboard+display+speaker+mouse+arms-length-proximity+stationary. If you add/remove/alter _any_ of those 6 constraints, then there's plenty of room for innovation, but those constraints _define_ a desktop computer.
One classic example is the "Bloomberg Box": https://en.wikipedia.org/wiki/Bloomberg_Terminal which has been around since the late '80s.
You can also see this from the reverse (analog -> digital) in the evolution of hospital patient life-sign monitors and the classic "6 pack" of gauges used in both aviation and automobiles.
Now with performant hypervisors, I just run a bunch of Linux VMs locally to minimize splash-zone and do cloud for performance computing.
I'll likely migrate fully to a Framework laptop next year, but I don't have time (atm) to do it. Ah, the good 'ole glory days of native Linux on Thinkpads.