Nicotine itself seems to be remarkably benign. Smoking is bad, snuff is bad.
From the second link:
>In this policy statement, 12 evidence-based key messages that highlight the CV [cardio vascular] toxicity of nicotine are presented, irrespective of delivery system.
So it doesn’t matter if it’s smoking, patches, gum, pouches, whatever. Nicotine is addictive and harmful. Perhaps not as harmful when it’s not combined with tobacco and all the other substances that come with cigarettes, but it’s not benign or harmless.