With a little extra smarts, the drive could deal with ISAM tables as well as files and do processing inside the drive itself. Things like sorting and indexing tables in dBase II could be done in the drive itself while the computer was doing things like updating screens.
OTOH, on the Apple II, the drive was so deeply integrated into the computer that accelerator boards needed to slow down the clock back to 1MHz when IO operations were running. Even other versions of the 6502 would need to have the exact same timings if they wanted to be used by Apple.